Topline study MSD-001 clinical trial results and lead fixed dose combination program announcement
Mindstate Design Labs Inc., a clinical-stage AI neuroengineering platform company, today announced results from its first-in-human Phase I study of MSD-001, a proprietary oral formulation of 5-MeO-MiPT under clinical evaluation for psychiatric conditions with high unmet need.
The trial confirmed that MSD-001 was safe and well-tolerated across dose ranges and delivered the first clinical validation of the Osmanthus platform's capacity to design psychoactive effects.
MSD-001 will serve as a neutral psychoactive base in multiple fixed-dose combinations designed to elicit specific acute psychoactive effects that may improve efficacy, decrease adverse events, broaden patient access, and open new treatment possibilities.
MSD-001 produced strong but narrowly defined psychoactive effects, no hallucinations, and markedly lower scores on non-visual Altered States of Consciousness scale dimensions compared to psychedelics. No serious adverse events were reported.
These results provide strong clinical validation of our Osmanthus platform and establish a solid foundation for advancing into trials, said Mindstate Design Labs CSO Dr. Robert Silva.
Mindstate Design Labs' Osmanthus platform incorporates machine learning and statistical models of relationships between biochemical targets and psychoactive effects.
The company will progress fixed-dose combinations based on MSD-001 into the next phase of clinical trials, with a lead program designed to elicit anxiolytic-like effects on mood, increase insight-related cognitive function, and upregulate aesthetic perception.
About Mindstate Design Labs
Mindstate Design Labs is a clinical-stage AI neuroengineering platform company developing novel classes of psychoactive therapeutics for psychiatric indications with high unmet need.
Mindstate Design Labs is backed by Y Combinator, Initialized Capital, Metaplanet, Day One Ventures, and angels including the founders of OpenAI, Neuralink, Instacart, Coinbase and Twitch.
Contact Information
Inquiries can be directed to info@mindstate.design.